Protein Family

Human Cysteine Cathepsins

Papain-like cysteine proteases represented in PapayaDB with structural models and cathepsin–glycosaminoglycan (GAG) interaction datasets.

Cysteine cathepsins are proteases belonging to the papain family. Predominantly located in lysosomes, their primary physiological roles include the degradation, inhibition, and processing of other proteins. The human genome encodes 11 cysteine cathepsins: B, C, F, L, K, V, S, X/Z, H, W, and O. They all share a conserved fold with catalytic residue pairs Cys25 and His159 (according to papain numbering) in their active site. GAG binding can alter their enzymatic stability, localization, and activity, making these interactions a critical target for biochemical modeling.

Cathepsin F

PDB Template: 1M6D

UniProt ID: Q9UBX1

Available Data:

AA MD RS-REMD CG N/A

Cathepsin X

PDB Template: 1EF7

UniProt ID: Q9UBR2

Available Data:

AA MD RS-REMD CG N/A

Cathepsin O

PDB Template: Only AlphaFold model available: AF-P43234-F1

UniProt ID: P43234

Available Data:

AA MD RS-REMD CG N/A

Cathepsin W

PDB Template: Only AlphaFold model available: AF-P56202-F1

UniProt ID: P56202

Available Data:

AA MD RS-REMD CG N/A

Cathepsin C

PDB Template: 2DJG

UniProt ID: P53634

Available Data:

AA MD RS-REMD CG N/A

Cathepsin H

PDB Template: 6CZK

UniProt ID: P09668

Available Data:

AA MD RS-REMD CG N/A

Cathepsin K

PDB Template: N/A

UniProt ID: N/A

Available Data:

AA MD RS-REMD CG MD

Cathepsin V

PDB Template: N/A

UniProt ID: N/A

Available Data:

AA MD RS-REMD CG N/A

Cathepsin B

PDB Template: N/A

UniProt ID: N/A

Available Data:

AA MD RS-REMD CG N/A

Cathepsin S

PDB Template: N/A

UniProt ID: N/A

Available Data:

AA MD RS-REMD CG MD

Cathepsin L

PDB Template: N/A

UniProt ID: N/A

Available Data:

AA MD RS-REMD CG MD